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KMID : 0043319990220010030
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Archives of Pharmacal Research
1999 Volume.22 No. 1 p.30 ~ p.34
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Metabolism of Liriodendrin and Syringin by Human Intestinal Bacteria and their Rlation to in Vitro Cytootoxicity
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Kim Dong-Hyun
Lee Kyung-Tae
Bae Eun-Ah
Han Myung-Joo
Park Hee-Juhn
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Abstract
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When liriodendrin or syringin was incubated for 24 h with human intestinal bacteria, two metabolites, (+)-syringaresinol--D-glucopyranoside and (+)-syringaresionl, from liriodendrin and one metabolite, synapyl alcohol, from syringin were produced. The metabolic time course of liriodendrin was as follows: at early time liriodendrin was converted to (+)-syringaresinol--D-glucopyranoside, and then (+)-syringaresinol. The in vitro cytotoxicities of these metabolites, (+)-syringaresinol and synapyl alcohol, were superior to those of liriodendrin and syringin.
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KEYWORD
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Liriodendrin, Syringin, Intestinal Bacteria, Cytotoxicity
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